The following LGR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LGR5 cDNA ORF which is encoded by the open reading frame (ORF) sequence.

The Wnt signaling pathway is a recurring theme in tissue development and homeostasis. Its specific roles during inner ear development are just emerging, but few studies have characterized Wnt target genes. Lgr5, a member of the G protein-coupled receptor family, is a Wnt target in the gastrointestinal and integumentary systems. Although its function is unknown, its deficiency leads to

Official gene symbol, which is typically a short form of the gene name, according to HGNC. LGR5. Gene descriptioni. 2019-07-29 · Lgr5, a Wnt target gene, has been widely used as a marker of organ stem cells with self-renewal capacity [41, 79], as well as an established biomarker of cancer stem cells (e.g., colorectal cancer and mammary tumors) . Simultaneously, Lgr5 has been recently reported to be essential for B cell development. LGR5_ENST00000540815 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, LGR5_ENST00000540815 Genome Browser, LGR5_ENST00000540815 References LGR5_ENST00000540815 - Explore an overview of LGR5_ENST00000540815, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

Lgr5 gene

Expression of Lgr5 protein in the human endometrium. Upper img. img 0. Addgene: HR180-LGR5-iCT img. img 1. LGR5 Gene - GeneCards | LGR5 Protein Interestingly, Lgr5 gene expression has been reported previously to be dispensable for ex vivo tumor organoid maintenance 38 . Notably, the deletion of Ap4 loss in the gene encoding for the mitochondrial transporter slc25a43 side for det tredje undertrykte knockdown av lgr5 supplementary fig.

2020-07-01 · To identify new populations of LGR5 + cells that are prone to tumorigenesis, we utilized the tamoxifen-inducible Lgr5 cre/ERT2 allele in crosses with mice harboring Arid1a fl and (Gt)R26Pik3ca *H1047R alleles, a potent combination of cancer driver genes in the ovary and uterus (Chandler et al., 2015, Wilson et al., 2019).

Other products for "LGR5". cDNA Clones. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from a panel of intestinal Wnt target genes for its restricted crypt expression. Here, using 2020-03-16 Gene information about ENSG00000139292 / LGR5 - leucine-rich repeat containing G protein-coupled receptor 5 We use cookies to enhance the usability of our website.

2021-03-30 · Lgr5 MGI Mouse Gene Detail - MGI:1341817 - leucine rich repeat containing G protein coupled receptor 5. View mouse Lgr5 Chr10:115450314-115587780 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. Home.

129 Among this gene signature was the View mouse Lgr5 Chr10:115450314-115587780 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression While the role of nuclear Lgr5 in the gastric epithelium and in cancer cells remains largely unexplored, it is worth noting that several studies examining Lgr5 (+) cells based their identification of Lgr5 (+) cells based on LGR5 mRNA expression and/or LGR5-driven reporters (ex. Lgr5-lacZ), where the sub-cellular localization of reporters may LGR5 plays an important role in the self-renewal of stem cells and is used as a marker identifying self-renewing stem cells in small intestine and hair follicles. Moreover, LGR5 has been reported to be overexpressed in several cancers. SOX9 is a transcription factor that plays a key role in developm … The Lgr5 gene, a target for the Wnt cell signalling system, has been identified as a unique single marker for stem cells in several adult tissues and in cancers. Lgr5 was first identified in colon The Wnt signaling pathway is a recurring theme in tissue development and homeostasis.

GO annotations related to this gene include transmembrane signaling receptor activity and G-protein coupled receptor activity. An important paralog of this gene is LHCGR. … LGR5 is the most selectively expressed gene in human zona glomerulosa and reduces aldosterone production and cell number. H pylori colonize and manipulate the progenitor and Lgr5(+)stem cell compartments, which alters turnover kinetics and glandular hyperplasia. Sequence variants and/or copy number variants (deletions/duplications) within the LGR5 gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported.
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Location_base_pair. Starts at 71439798 and ends at 71586308 bp from pter ( according to hg38-Dec_2013) Fusion genes. (updated 2017) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) KIAA1033 (12q23.3) / LGR5 (12q21.1) 2020-06-10 LGR5 A gene on chromosome 12q22-q23 that encodes an orphan G protein-coupled receptor that is the stem cell marker of the intestinal epithelium and hair follicles.

LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5) is a Protein Coding gene. Diseases associated with LGR5 include Colon Adenoma and Ankyloglossia With Or Without Tooth Anomalies. Among its related pathways are Signaling by GPCR and mTOR signaling pathway (KEGG). LGR5 is the most selectively expressed gene in human zona glomerulosa and reduces aldosterone production and cell number.
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The MANE Select is a default transcript per human gene that is representative of biology, well-supported, expressed and highly-conserved. This transcript set matches GRCh38 and is 100% identical between RefSeq and Ensembl/GENCODE for 5' UTR, CDS, splicing and 3'UTR. MANE Select v0.92, LGR5-203: ENST00000540815.2

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